TYPE I INTERFERON BLOCKING AGENTS FOR PREVENTION AND TREATMENT OF PSORIASIS
摘要
<p>The discovery of plasmacytoid dendritic cell precursors (PDC) as crucial effector cells with high production of type I interferons (IFNs) in early psoriasis development has led to the present invention that blocking of type I IFNs can be used for prevention and therapy of psoriasis. The invention relates to the use of a type I interferon blocking agent, such as a type I IFN antagonist (e.g. an anti-IFN-a antibody) or type I IFN receptor antagonist, for the preparation of a medicament for the prevention and treatment of psoriasis, and to a method of prevention and treatment of psoriasis using a type I interferon blocking agent.</p>
申请公布号
WO2006037247(A1)
申请公布日期
2006.04.13
申请号
WO2005CH00566
申请日期
2005.09.30
申请人
UNIVERSITAET ZUERICH;GILLIET, MICHEL;NESTLE, FRANK, O.