发明名称 |
Processes for preparing and purifying carbostyril compounds such as aripiprazole and 7-(4-halobutoxy)-3,4-dihydro-2(1H)-quinolinones |
摘要 |
The present invention provides several improved processes for preparing aripiprazole, wherein the first step comprising reacting 7-HQ with a 1,4-disubstituted-butane in biphasic reaction mixture or in a single phase solvent to obtain a 7-(4-halobutoxy)-3,4-dihydro-(1H)-quinolinone (7-HBQ) and the second step comprising reacting the 7-HBQ and 1-(2,3-dichlorophenyl)piperazine or an acid addition salt thereof in a biphasic reaction medium containing water and a water-immiscible solvent to obtain aripiprazole. Also provided are methods of purifying the 7-HBQs and aripiprazole.
|
申请公布号 |
US2006079689(A1) |
申请公布日期 |
2006.04.13 |
申请号 |
US20050246279 |
申请日期 |
2005.10.11 |
申请人 |
NADDAKA VLADIMIR;BRAND MICHAEL;DAVIDI GUY;KLOPFER EYAL;GRIBUN IRINA;ARAD ODED;KASPI JOSEPH |
发明人 |
NADDAKA VLADIMIR;BRAND MICHAEL;DAVIDI GUY;KLOPFER EYAL;GRIBUN IRINA;ARAD ODED;KASPI JOSEPH |
分类号 |
C07D403/02 |
主分类号 |
C07D403/02 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|