Derivatives of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)alkyl]phosphonic acid and methods of making them

摘要

Compounds of formula (I) or pharmaceutically acceptable salts thereof are provided: wherein: A is alkylenyl of 1 to 4 carbon atoms, or alkenylenyl of 2 to 4 carbon atoms; R₁ and R₂ are, independently, hydrogen or a C₅ to C₇ aryl optionally substituted with 1 to 2 substituents, independently, selected from the group consisting of -C(O)R₃, halogen, cyano, nitro, hydroxyl, C₁-C₆ alkyl, and C₁-C₆ alkoxy, with the proviso that at least one of R₁ and R₂ is not hydrogen; R₃ is, independently, hydrogen, -OR₄, alkyl, aryl, or heteroaryl; R₄ is hydrogen, alkyl, aryl, or heteroaryl; R₅ and R₆ are, independently, hydrogen, alkyl, hydroxyl, alkoxy, or C₅ to C₇ aryl; wherein any R₃ to R₆ group having an aryl or heteroaryl moiety can optionally be substituted on the aryl or heteroaryl moiety with 1 to about 5 substituents, independently, selected from the group consisting of halogen, cyano, nitro, hydroxyl, C₁-C₆ alkyl, and C₁-C₆ alkoxy. Methods of making these compounds as well as methods using the compounds for treating a variety of conditions are also disclosed.