DIAGNOSIS AND THERAPY OF CELL PROLIFERATIVE DISORDERS CHARACTERIZED BY RESISTANCE TO TRAIL INDUCED APOPTOSIS

摘要

Described are methods and compounds for diagnosis and therapy of subsets of cell proliferative disorders which are characterized by resistance to TRAIL induced apoptosis. Examples of such diseases are B-cell chronic lymphocytic leukemia (CLL), mantle cell lymphoma (MCL) and prostate cancer. Furthermore, methods for identifying drugs which are suitable for treatment of such diseases are described.