发明名称 PHARMACEUTICAL COMPOSITION CONTAINING SODIUM {[3-(2-AMINO-1,2-DIOXOETYL)-2-ETHYL-1-(PHENYLMETHYL)-1H-INDOL-4-YL]OXY}ACETATE AS PHOSPHOLIPASE INHIBITOR
摘要 PROBLEM TO BE SOLVED: To stably keep sodium ä[3-(2-amino-1,2-dioxoethyl)-2-ethyl-1-(phenylmethyl)-1H-indol-4-yl]oxy}acetate (referred to as a compound (I)) in an aqueous carrier, and to provide a high-quality, excellent lyophilized formulation containing the compound (I), keeping homogeneous phase, good in reproduction, and causing no disintegration thereof during storage. SOLUTION: The lyophilized pharmaceutical formulation comprises the compound (I), a dissolution agent and a stabilizer. Such a formulation is stable during storage, being readily soluble in an aqueous medium to provide a solution injectible in treating e.g. septicemia. COPYRIGHT: (C)2006,JPO&NCIPI
申请公布号 JP2006096761(A) 申请公布日期 2006.04.13
申请号 JP20050330964 申请日期 2005.11.16
申请人 SHIONOGI & CO LTD;ELI LILLY & CO 发明人 CONFER WILLIAM LESTER;TAI HIDEAKI
分类号 A61K31/4045;A61K47/10;A61K9/00;A61K9/19;A61K31/404;A61K47/12;A61K47/16;A61K47/24;A61K47/26;A61P29/00;A61P31/04;C07D209/42 主分类号 A61K31/4045
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