METHOD FOR INHIBITING FIBROGENESIS BY AN RHDECORIN-FC FUSION PROTEIN

摘要

The present invention relates to methods for inhibiting liver fibrogenesis in vitro and/or in vivo with directly administered recombinant rhDecorin and rhDecorin-Fc fusion protein. In one embodiment a linker is provided between Decorin and the Fc hinge fragment to form a fusion protein which increases the biologic activity of Decorin and increases the ability to bind to TGF-ß and extends the lifetime of decorin in serum, where the Fc hinge fragment is a modified form of Fc involving the replacement of four N-terminal amino acids with ten different amino acids which extends the lifetime of the Decorin-Fc protein by 50%.