CREATION OF SHEAR IN A REACTOR

摘要

An apparatus for performing a biological or biochemical reaction that, in certain embodiments, has the ability to apply shear stress to a component of a liquid sample and includes a biological or biochemical reactor comprising a container having a volume of less than about 2 mL and containing a liquid sample, and a shear-generating element, the shear-generating element being contained within the apparatus and constructed and arranged so that the entire shear-generating element moves along a selected path of motion intersecting a first location within the apparatus and a second location within the apparatus, with or without rotational movement is described. A method of applying shear stress to a component of a liquid sample that includes moving a liquid or gaseous shear-generating element within an apparatus along a selected path of motion to create a reproducible and controllable level of shear stress at a selected location within the liquid sample is also disclosed.