SPECTROSCOPIC DETERMINATION OF ENANTIOMERIC PURITY
摘要
<p>A new method and strategy for the quantitative determination of enantiomeric purity that combines polarimetry, spectroscopy, and chemometric modeling. Spectral data is collected after a light beam is passed through a first polarimeter, a sample of a chiral compound, and a second polarimeter oriented at a 45 degree angle relative to the first polarimeter. The spectral data for samples of known enantiomeric composition is subjected to a type of multivariate regression modeling known as partial least squares ("PLS-1") regression. The PLS-1 regression produces a mathematical model that can be used to predict the enantiomeric composition of a set of samples of unknown enantiomeric purity.</p>
申请公布号
WO2006039648(A1)
申请公布日期
2006.04.13
申请号
WO2005US35481
申请日期
2005.09.30
申请人
BAYLOR UNIVERSITY;BUSCH, KENNETH, W.;RABBE, DENNIS, H.