PREVENTIVE AND/OR THERAPEUTIC AGENT FOR URINE COLLECTION DISORDER ACCOMPANYING LOWER URINARY TRACT OBSTRUCTION

摘要

A preventive and/or therapeutic agent for urine collection disorders accompanying lower urinary tract obstruction, characterized by containing an indoline derivative represented by the following general formula (I): [Chemical formula 1] (wherein R represents optionally substituted aliphatic acyl optionally having an unsaturated bond, hydroxyalkyl, aliphatic acyloxyalkyl, lower alkoxy, carboxy, lower alkoxycarbonyl, aryl(lower alkoxy)carbonyl, carbamoyl, (mono- or dialkyl)carbonyl or cyano(lower alkyl), optionally halogenated aromatic acyl, furoyl, or pyridylcarbonyl; R¹ represents cyano or carbamoyl; and R² represents lower alkyl optionally having a halogen atom, cyano group, or aryl group), or a pharmacologically acceptable salt of the derivative. The derivative and salt are usable as a preventive and/or therapeutic agent for urine collection disorders accompanying lower urinary tract obstruction.