PROCESS FOR PRODUCING 4'-BROMOMETHYL-2-CYANOBIPHENYL

摘要

The present invention relates to a method of producing 4'-bromomethyl-2-cyanobiphenyl, which includes reacting 4'-methyl-2-cyanobiphenyl with bromine in the presence of a radical initiator and an oxidant. According to the present invention, 4'-bromomethyl-2-cyanobiphenyl useful as a starting material of a pharmaceutical product can be produced industrially advantageously because, using an oxidant, bromine can be reproduced from hydrogen bromide by-produced as the bromination reaction proceeds, which in turn enables prevention of inhibition of the reaction due to hydrogen bromide, coloration due to bromine and the like.