发明名称 |
COMPOSITIONS AND METHODS FOR TREATING COAGULATION RELATED DISORDERS |
摘要 |
Disclosed are methods for preventing or treating sepsis, a sepsis-related condition or an inflammatory disease in a mammal. In one embodiment, the method includes administering to the mammal a therapeutically effective amount of at least one humanized antibody, chimeric antibody, or fragment thereof that binds specifically to tissue factor (TF) to form a complex in which factor X or factor IX binding to the complex is inhibited and the administration is sufficient to prevent or treat the sepsis in the mammal. The invention has a wide spectrum of useful applications including treating sepsis, disorders related to sepsis, and inflammatory diseases such as arthritis. |
申请公布号 |
EP1644039(A2) |
申请公布日期 |
2006.04.12 |
申请号 |
EP20040754498 |
申请日期 |
2004.06.04 |
申请人 |
TANOX, INC. |
发明人 |
JIAO, JIN-AN;WONG, HING, C.;EGAN, JACK, O. |
分类号 |
A61K39/395;A61K;A61K39/40;A61K39/42;A61P7/02;C07K16/00;C07K16/36;C12P21/08;G01N33/53;(IPC1-7):A61K39/40 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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