发明名称 |
Small organic molecule regulators of cell proliferation |
摘要 |
The present invention makes available methods and reagents for modulating proliferation or differentiation in a cell or tissue comprising contacting the cell with a hedgehog agonist, such as the compounds depicted in Figures 32 and 33. In certain embodiments, the methods and reagents may be employed to correct or inhibit an aberrant or unwanted growth state, e.g., by antagonizing a normal ptc pathway or agonizing smoothened or hedgehog activity.
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申请公布号 |
EP1645275(A1) |
申请公布日期 |
2006.04.12 |
申请号 |
EP20050021670 |
申请日期 |
2001.03.30 |
申请人 |
CURIS, INC. |
发明人 |
BAXTER, ANTHONY DAVID;BOYD, EDWARD ANDREW;PRICE, STEPHEN;RUBIN, LEE E.;FRANK-KAMENETSKY, MARIA;GUICHERIT, OIVIN M.;PORTER, JEFFREY |
分类号 |
A61K31/50;A61K31/517 |
主分类号 |
A61K31/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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