| 摘要 |
1-(1-Hydroxy-1-phenyl-4-aminobutyl)-and 1-(1-phenyl-4-aminobutenyl)-adamantane derivatives in which the phenyl ring may be chloro, trifluoromethyl, methyl, methoxy or methylthio substituted and the amino group may be dilower-alkylamino, N-piperidinyl, N-pyrrolidinyl, N'-lower alkyl-N-piperazinyl or N-morpholinyl are useful as tranquilizers. The compounds are generally prepared by reaction of an appropriate 1-adamantyl phenyl ketone with an aminopropyl magnesium halide to give the hydroxybutanes followed by acid dehydration to furnish the butene derivatives.
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