| 摘要 |
The present invention relates to nucleotide sequences, including expressed sequence tags (ESTs), oligonucleotide probes, polypeptides, vectors and host cells expressing, and immunoadhesions and antibodies to mammalian GFRalpha3, a novel alpha-subunit receptor of the GDNF (i.e. GFR) receptor family. It further relates to an assay for measuring activation of an alpha-subunit receptor by detecting tyrosine kinase receptor activation (i.e., autophosphorylation) or other activities related to ligand-induced alpha-subunit receptor homo-dimerization or homo-oligomerization.
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