发明名称 |
Recombinant protein production in bovine adenovirus expression vector system |
摘要 |
The present invention relates novel live bovine adenovirus (BAV) expression vector systems in which part or all of one or both of the early region 1 (E1) and early region 3 (E3) genes are deleted and replaced by a foreign gene or fragment thereof and novel recombinant mammalian cell lines stably transformed with BAV E1 sequences, and therefore, express E1 gene products capable of allowing replication therein of a bovine adenovirus having an E1 deletion replaced by a heterologous nucleotide sequence encoding a foreign gene or fragment thereof and their use in production of (antigenic) polypeptides or fragments thereof for the purpose of live recombinant virus or subunit vaccine or for other therapies.
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申请公布号 |
US7025967(B2) |
申请公布日期 |
2006.04.11 |
申请号 |
US20020046938 |
申请日期 |
2002.01.14 |
申请人 |
UNIVERSITY OF SASKATCHEWAN |
发明人 |
MITTAL SURESH K.;GRAHAM FRANK L.;PREVEC LUDVIK;BABIUK LORNE A. |
分类号 |
A61K39/235;A61K39/295;A61K48/00;C07K14/075;C12N7/01;C12N15/861 |
主分类号 |
A61K39/235 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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