发明名称 |
Peptide antagonists of the human urokinase receptor and method for selecting them |
摘要 |
A novel set of inhibitors of the binding interaction between human urokinase plasminogen activator (uPA) and its cell surface receptor (uPAR) has been developed. The inhibitors comprise of peptide fragments, monomeric or in multiple copies attached to a common scaffold, in which the amino acid sequence may include uncommon substituted amino acids to partially comprise of peptoid sequences. The present invention also relates to the use of such peptides in therapy, in particular for the treatment of cancer, having developed a modified non-human mammalian receptor to which the novel inhibitors are antagonistic.
|
申请公布号 |
US7026282(B1) |
申请公布日期 |
2006.04.11 |
申请号 |
US20010743329 |
申请日期 |
2001.12.26 |
申请人 |
CANCERFORSKNINGSFONDEN AF 1989 (FONDEN TIL FREMMEAF EXSPERIMENTEL CANCERFORSKNING) |
发明人 |
PLOUG MICHAEL;OESTERGAARD SOEREN;HOLST-HANSEN CLAUS;STEPHENS ROSS;DANOE KELD;HOLM ARNE |
分类号 |
C07K7/00;A61K38/00;C07K7/06;C12N9/72;G01N33/68 |
主分类号 |
C07K7/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|