N-Substd. and N,N-Disubstd. aminocarbonylalkyl cpds. - having anti-inflammatory and/or anti-arrhythmic activity

摘要

N-substd. - and N, N-disubstd.-aminocarbonyl-alkyl compounds of general formula (I): Z =-S or lower alkylimino; A = lower alkylene; R1 = H, halogen, lower alkyl, lower alkoxy or trifluoromethyl; R2 = H, alkyl or hydroxy-alkyl R3 = H, alkyl, halo alkyl, hydroxy-alkyl, alkanoyloxy-alkyl, alkoxy-alkyl, hydroxy-alkoxy-alkyl, hydroxycarbonyl-alkyl, alkoxycarbonyl-alkyl, phenyl opt. substd. by one or more alkyl, halogen, hydroxy, alkoxy and/or alkanoyl; phenyl-alkyl opt. nuclearly substd. by one or more halogen, hydroxy, lower alkoxy and/or alkanoyl; or a group -A1 - NR4R5; or NR2R3 may form a 3-7 membered heterocyclic ring. A1 = lower alkylene; R4 and R5 = alkyl or phenyl or form together with N a 5-7 membered heterocyclic ring; R1 cannot be H when R2 and R3 are lower alkyl or form together with N a alkylene group or form together an oxa-alkylene group. R1 cannot be Cl when R2 and R3 are both H. (I) Have anti-inflammatory and/or antiarrhythmic activity and may be used in the treatment of inflammations and certain cases of arrhythmia e.g. conversion of atric fibrillation, abolition of paroxysmal atric tachycardia and control of ventricular ectopic beats.