NOVEL AZABICYCLIC RING AMMONIUMS AND THEIR USE FOR TREATING PROTEIN AGING DISEASE

摘要

The present invention relates to azabicyclic ring ammoniums of general formula I in which the definition of each radical is described in the specification and/or their pharmaceutically acceptable salts and hydrates; pharmaceutical compositions comprising the same, also to the uses of those compositions for the preparation of medicaments for (i) improving the elasticity or reducing wrinkles of the skin, (ii) treating diabetes, (iii) treating or ameliorating adverse sequelae of diabetes, (iv) treating or ameliorating kidney damage, (v) treating or ameliorating blood vasculature, (vi) treating or ameliorating hypertension, (vii) treating or ameliorating retinopathy, (viii) treating or ameliorating damage to lens proteins, (ix) treating or ameliorating cataracts, (x) treading or ameliorating peripheral neuropathy, (xi) treating or ameliorating osteoarthritis, or use for the preparation of a buccal medicament for preventing or reversing the staining of teeth, or the use for the preparation of various freshness keeper for crops plant protein, animal protein.