NANOPARTICULATE PROBE FOR IN VIVO MONITORING OF TISSUE OXYGENATION

摘要

A new class of micro- and nano- particulate paramagnetic spin probes especially useful for magnetic resonance imaging techinques, including electron paramagnetic resonance (EPR) and magnetic resonance imaging (MRI). The probes are lithium phthalocyanine derivative compounds. Also provided are are suspensions and emulsions comprising lithium phthalocyanine derivative probes. Also provided are noninvasive methods for measuring noninvasive methods of measuring oxygen concentration, oxygen partial pressure, oxygen metabolism, and nitric oxide concentration in a specific tissue, organ, or cell in vivo or in vitro.