发明名称 |
Tryptophan as a functional replacement for adp-ribose-arginine in recombinant proteins |
摘要 |
A method is disclosed for producing a polypeptide with a modified activity or stability, by replacing an arginine residue capable of being ADP-ribosylated with a tryptophan or a phenylalanine. In one embodiment, compositions are provided that include polypeptides, such as alpha defensin, with arginine-to-tryptophan or arginine-to-phenylalanine substitutions, where the arginine residue is capable of being ADP-ribosylated. In another embodiment, methods are disclosed for modifying an immune response in a subject.
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申请公布号 |
US2006074037(A1) |
申请公布日期 |
2006.04.06 |
申请号 |
US20040517565 |
申请日期 |
2004.12.07 |
申请人 |
MOSS JOEL;STEVENS LINDA;BOURGEOIS CHRISTELLE;BORTELL RITA |
发明人 |
MOSS JOEL;STEVENS LINDA;BOURGEOIS CHRISTELLE;BORTELL RITA |
分类号 |
A61K48/00;C12N15/09;A61K38/00;A61K38/17;A61P31/00;A61P37/04;C07H21/04;C07K1/107;C07K14/47;C12N9/10;C12N15/55;C12P21/02;C12Q1/48 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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