REGULATION OF CARDIAC CONTRACTILITY AND HEART FAILURE PROPENSITY

摘要

The methods and compositions of the present invention find use in altering expression of PKCalpha in transgenic animals. The compositions of the invention include isolated transgenic animal cells, transgenic tissue, and transgenic mice. The transgenic animals of the invention exhibit altered PKCalpha activity. The methods allow generation of transgenic animals with altered expression of PKCalpha. The invention allows modulation of cardiac contractility. In particular, the invention provides a method for altering the susceptibility of a transgenic animal to cardiomyopathy. A transgenic animal of the invention finds use in identifying anti-cardiomyopathic compounds.