发明名称 |
MULTIVALENTER HUMAN-BOVINER ROTAVIRUS-IMPFSTOFF |
摘要 |
<p>The present invention provides vaccine compositions for protection against human rotaviral disease without significant reactogenicity. Human×bovine reassortant rotavirus comprising each of the four clinically most important VP7 serotypes of human rotavirus are combined in a multivalent formulation which provides a high degree of infectivity and immunogenicity without producing a transient febrile condition. Methods for producing an immunogenic response without producing a transient febrile condition are also provided.</p> |
申请公布号 |
DE69929443(D1) |
申请公布日期 |
2006.04.06 |
申请号 |
DE1999629443 |
申请日期 |
1999.07.27 |
申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA ASREPRESENTED BY THE SECRETARY OF THE DEPARTMENT OFHEALTH AND HUMAN SERVICES, BETHESDA |
发明人 |
KAPIKIAN, Z.;CHANOCK, M.;HOSHINO, YASUTAKA |
分类号 |
A61K39/12;A61K39/15;A61P31/12;A61P31/14 |
主分类号 |
A61K39/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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