MOUSE SPERMATOGENESIS GENES, HUMAN MALE STERILITY-ASSOCIATED GENES AND DIAGNOSTIC SYSTEM USING THE SAME

摘要

The present invention provides a group of mouse spermatogenesis genes, which is an assembly of 89 genes in total, wherein the respective genes transcribe mRNAs from which cDNAs having the respective base sequences of SEQ ID NOs:1 to 89 are synthesized; an Scot-t gene mutation and a protamine-2 gene mutation which are human homologues of genes belonging to the group of mouse genes and associated with human male infertility. The invention also provides a group of mouse spermatogenesis genes and various molecular biological materials relating thereto; various molecular biological materials relating to male infertility-associated gene mutations; and various test methods and diagnostic methods using the same.