发明名称 |
FUCOSE TRANSPORTER |
摘要 |
<p>The present invention provides a gene encoding a fucose transporter, a fucose transporter polypeptide, a method for screening for a compound that binds to a fucose transporter or a compound that inhibits fucose transport activity, a cell having inhibited fucose transporter functions, and a cell wherein the expression of the fucose transporter is inhibited. The present invention further relates to a method for producing recombinant protein, and specifically, to a method for producing protein by which fucose existing within the Golgi apparatus of a host cell is decreased, a method for inhibiting the addition of fucose to protein by which fucose existing within the Golgi apparatus of a host cell is decreased upon production of recombinant protein using the host cell, a method for increasing the cytotoxic activity of an antibody by which an antibody is produced using a cell wherein fucose existing within the Golgi apparatus is decreased, and a cell having a Golgi apparatus wherein fucose existing within the Golgi apparatus is decreased.</p> |
申请公布号 |
EP1642971(A1) |
申请公布日期 |
2006.04.05 |
申请号 |
EP20040746425 |
申请日期 |
2004.06.18 |
申请人 |
CHUGAI SEIYAKU KABUSHIKI KAISHA |
发明人 |
TSUCHIYA, MASAYUKI;IIJIMA, SHIGEYUKI;SUGO, IZUMI;SEKIMORI, YASUO;UENO, KENJU;HABU, KIYOSHI |
分类号 |
C07K14/47;C12P21/00;C12P21/08;(IPC1-7):C12N15/11;C12Q1/68;C12N15/00;C12N5/10;G01N33/53;C12P21/02 |
主分类号 |
C07K14/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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