发明名称 Echinocandin derivatives, method for preparing same and application as antifungal agents
摘要 A subject of the invention, in all possible isomer forms as well as their mixtures, is the compounds of formula (I): in which either R<SUB>1</SUB>: H or CH<SUB>3 </SUB>and R<SUB>2</SUB>: cyclohexyl substituted by an amine, a (CH<SUB>2</SUB>)b-C≡N radical or R<SUB>1 </SUB>and R<SUB>2 </SUB>together with the nitrogen which carries them form a ring with 3, 4 or 5 carbons optionally substituted by an amine R<SUB>3</SUB>: hydrogen, methyl or hydroxyl R<SUB>4</SUB>: hydrogen or hydroxyl R: represents a linear, branched or cyclic chain T: hydrogen, methyl, CH<SUB>2</SUB>CONH<SUB>2</SUB>, CH<SUB>2</SUB>C≡N, a (CH<SUB>2</SUB>)<SUB>2</SUB>NH<SUB>2 </SUB>or (CH<SUB>2</SUB>)<SUB>2</SUB>Nalk<SUP>+</SUP>X<SUP>-</SUP> radical, X halogen and alk alkyl Y: hydrogen, hydroxyl, halogen or OSO<SUB>3</SUB>H, W: H or OH, Z: H, CH<SUB>3</SUB>. The compounds of formula (I) have antifungal properties.
申请公布号 US7022669(B1) 申请公布日期 2006.04.04
申请号 US20010018073 申请日期 2001.12.21
申请人 AVENTIS PHARMA S.A. 发明人 FAUVEAU PATRICK;HAWSER STEPHEN;LEBOURG GILLES;SCHIO LAURENT
分类号 A61K38/00;A61K38/12;A61P31/04;A61P31/10;C07K7/06;C07K7/56 主分类号 A61K38/00
代理机构 代理人
主权项
地址