发明名称 |
Cognition enhancing derivatives of isoxazole triazoloindane GABA-A alpha5 receptor subunit ligands |
摘要 |
The present invention relates to compounds of formula I: in which R<SUP>1 </SUP>is a linear group or a five membered heterocycle optionally fused to a phenyl ring, R<SUP>2 </SUP>is a 5-membered heterocycle, R<SUP>3 </SUP>is chosen from a range of substituents, m is 0-3 and n is 0 or 1; the compounds are generally inverse agonists at GABA-A receptors containing the alpha 5 subunit and so are useful in methods of enhancing cognition in subjects with diminished cognition in diseases such as Alzheimer's Disease.
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申请公布号 |
US7022724(B2) |
申请公布日期 |
2006.04.04 |
申请号 |
US20020277450 |
申请日期 |
2002.10.22 |
申请人 |
MERCK SHARP & DOHME LTD. |
发明人 |
BOASE AMANDA LOUISE;LADDUWAHETTY TAMARA;MACLEOD ANGUS MURRAY;MERCHANT KEVIN JOHN |
分类号 |
A61K31/422;A61K31/42;A61K31/427;C07D487/02;C07D487/04;C07D489/04 |
主分类号 |
A61K31/422 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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