发明名称 |
Heterodimeric conjugates of neomycin-chloramphenicol having an enhanced specificity against RNA targets and its preparation |
摘要 |
The present invention relates to heterodimeric conjugates of neomycin-chloramphenicol, of formula 1, their preparation and their use. Because of their heterodmieric structure, they can recognize both stem and loop of RNA motif and show binding ability to a certain RNA such that they have an enhanced pharmaceutical efficacy and reduced side effect which can be caused by non-specific drugs. For these reasons, they can be effectively used as an antiviral agent, an antibacterial agent or an anticancer drugs.
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申请公布号 |
US7022839(B2) |
申请公布日期 |
2006.04.04 |
申请号 |
US20040496275 |
申请日期 |
2004.05.21 |
申请人 |
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY |
发明人 |
YU JAEHOON;LEE JONGKOOK;KWON MIYUN;SHIN KYE-JUNG |
分类号 |
C07H1/00;C07H5/10;C07H15/232 |
主分类号 |
C07H1/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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