摘要 |
The invention relates to the use of derivatives of E-type prostaglandins as EP<SUB>2 </SUB>agonists, in general, and, in particular as ocular hypotensives. The PGE derivatives used in accordance with the invention are represented by the following formula I: wherein the hatched segment represents an alpha bonds, the solid triangle represents a beta bond, the wavy segments represent alpha or beta bond, dashed lines represent a double bond or a single bond, X is selected from the group consisting of hydrogen and halogen radicals, R<SUP>3 </SUP>is heteroaryl or a substituted heteroaryl radical, R<SUP>1 </SUP>and R<SUP>2 </SUP>are independently selected from the group consisting of hydrogen or a lower alkyl radical having up to six carbon atoms, or a lower acyl radical having up to six carbon atoms, R is selected from the group consisting of CO<SUB>2</SUB>R<SUP>4</SUP>, CONR<SUP>4</SUP><SUB>2</SUB>, CH<SUB>2</SUB>OR<SUP>4</SUP>, CONR<SUP>4</SUP>SO<SUB>2</SUB>R<SUP>4</SUP>, P(O)(OR<SUP>4</SUP>) and wherein R<SUP>4 </SUP>is selected from the group consisting of H, phenyl and lower alkyl having from one to six carbon atoms and n is 0 or an integer of from 1 to 4.
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