发明名称 Methods for attaching proteins to lipidic microparticles with high efficiency
摘要 The invention provides methods of attaching proteins to lipidic microparticles with efficiencies of at least 77%. The proteins are attached to linker molecules comprising a hydrophilic domain and a hydrophobic domain. The proteins can be antibodies, antibody fragments, hormones, growth factors, enzymes, or nucleic acid binding proteins, or other proteins. The proteins can be chemically conjugated to the linker molecules, or they can be fused to the linker molecules by recombinant techniques.
申请公布号 US7022336(B2) 申请公布日期 2006.04.04
申请号 US20040847982 申请日期 2004.05.17
申请人 THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 发明人 PAPAHADJOPOULOS DEMETRIOS;HONG KEELUNG;ZHENG WEIWEN;KIRPOTIN DMITRI B.
分类号 A61K9/127;C12N15/09;A61K9/00;A61K31/7105;A61K31/711;A61K47/10;A61K47/34;A61K47/48;A61K48/00;C07H21/00;C07H21/02;C07H21/04;C12N15/88 主分类号 A61K9/127
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