| 摘要 |
<p>The present invention is directed to an improved process for producing a catechol derivative (1) useful as an intermediate of pharmaceuticals and agricultural chemicals. The process is characterized in that formulation in the first ste p is carried out in the two stages, that is, the reaction is carried out in the presence of a tin catalyst at 60-85.degree.C to a conversion of 30 to 80% and then is complete d at 95=105.degree.C to produce a salicylaldehyde derivative (3) in a high yield and a high selectivity. Thereby, the objective catechol derivative (1) can be obtained in a high yie ld and with a high purity. As shown below wherein R is alkyl, cycloalkyl, aralkyl, alkoxy, halogen atom, allyl, or ary l, and R1 is a hydroxy protective group.</p> |
