发明名称 |
Process for the biological production of L-pipecolic acid |
摘要 |
A process for the production of L-pipecolic acid which comprises the step of reducing delta-1-piperideine-6-carboxylic acid by the use of pyrroline-5-carboxylate reductase. The delta-1-piperideine-6-carboxylic acid is obtained by the step of converting L-lysine by the use of lysine 6-aminotransferase encoded by a gene of Flavobacterium lutescens. The steps of reducing delta-1-piperideine-6-carboxylic acid and the converting of L-lysine into L-pipecolic acid by the use of lysine 6-aminotransferase are carried out by using a bacterium transformed with a gene encoding lysine 6-aminotransferase wherein such bacterium comprises pyrroline-5-carboxylate reductase encoded by a gene of Escherichia coli or a coryneform bacterium. A recombinant bacterium which can be used in this production process is also provided. Thus, the present invention can provide an efficient biological process for the production of L-pipecolic acid (or 2-piperidinecarboxylic acid).
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申请公布号 |
US7022502(B2) |
申请公布日期 |
2006.04.04 |
申请号 |
US20020169257 |
申请日期 |
2002.06.28 |
申请人 |
MERCIAN CORPORATION |
发明人 |
FUJII TADASHI;ARITOKU YASUHIDE;MUKAIHARA MANABU;NARITA TAKAO;AGEMATU HITOSI;ISSHIKI KUNIO |
分类号 |
C12P17/00;C12N1/21;C12N9/06;C12N15/54;C12P17/12 |
主分类号 |
C12P17/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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