Prodrugs of phosphonate nucleotide analogues and methods for selecting and making same
摘要
Disclosed is a method for use of magnesium alkoxide comprising reacting 9-(2-hydroxypropyl)adenine (HPA) or 9-(2-hydroxyethyl)adenine (HEA), magnesium alkoxide, and protected p-toluenesulfonyloxymethylphosphonate to form respectively compounds of the formulae (I) or (II).
申请公布号
NZ536942(A)
申请公布日期
2006.03.31
申请号
NZ20010536942
申请日期
2001.07.20
申请人
GILEAD SCIENCES, INC
发明人
BECKER, MARK W;CHAPMAN, HARLAN H;CIHLAR, TOMAS;EISENBURG, EUGENE J;HE, GONG-XIN;LEE, WILLIAM A;PRISBE, ERNEST J;ROHLOFF, JOHN C;SPARACINO, MARK L;KERNAN, MICHAEL R
