摘要 |
Disclosed are compounds of formula I, wherein; Q is SO2, CO, CONR9 or CSNR10, N is 2 or 3, R1 and R2 are independently H, halogen, CN, OCO2R12, CO2R13, CONR14R15, CNR16NR17R18, SOmR19, NR20R21, OR22, COR23 or alkyl, alkenyl, alkynyl, cycloalkyl, cycloheteroalkyl, aryl or heteroaryl, each optionally substituted, R3 and R4 are independently H or alkyl, R5 and R6 are independently H or alkyl, alkenyl, alkynyl, cycloalkyl, cycloheteroalkyl, aryl or heteroaryl, each optionally substituted, or R5 and R6 are taken together to form an optionally substituted 5- to 7-membered ring optionally containing an additional heteroatom, R7 is H, halogen or alkyl, alkoxy, aryl or heteroaryl, each optionally substituted, R8 is an optionally substituted bicyclic or tri-cyclic ring system having a N atom at a bridgehead and optionally additional heteroatoms. The compounds are used in the manufacture of medicaments for the treatment of disorders of the central nervous system related to or affected by the 5-HT6 receptor.
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