INCLUSION COMPLEXES OF ARYL-HETEROCYCLIC SALTS

摘要

COMPOSITIONS OF MATTER COMPRISING A PHARMACEUTICALLY ACCEPTABLE SALT OF AN ARYL-HETEROCYCLIC COMPOUND, SUCH AS ZIPRASIDONE IN A CYCLODEXTRIN. PREFERRED CYCLODEXTRINS ARE SBECD AND HPBCD. THE COMPOSITION CAN COMPRISE A DRY MIXTURE, A DRY INCLUSION COMPLEX OR AN AQUEOUS SOLUTION. THE SALT/CYCLODEXTRIN INCLUSION COMPLEX PREFERABLY PROVIDES AN AMOUNT OF ZIPRASIDONE OF AT LEAST 2.5MGA/ML WHEN THE COMPLEX IS DISSOLVED IN WATER AT 40W/V. A VARIETY OF ZIPRASIDONE SALTS ARE PREFERRED, INCLUDING THE MESYLATE, ESYLATE, BESYLATE, TARTRATE, NAPSYLATE AND TOSYLATE.