| 摘要 |
THIS INVENTION RELATES TO A TRAMADOL N-OXIDE MATERIAL, ENANTIOMERS AND COMPOSITIONS THEREOF AND THEIR USE. THE TRAMADOL N-OXIDE MATERIAL AND COMPOSITIONS THEREOF ARE PHARMACOLOGICALLY USEFUL IN TREATING PAIN. DIARRHEA AND TUSSIVE CONDITIONS. THE TRAMADOL N-OXIDE IS ALSO SUBJECT TO LESS SIDE-EFFECTS AS COMPARED TO PURE OPIATE BASED COMPOSITIONS, SUCH AS ABUSE LIABILITY, TOLERANCE, CONSTIPATION AND RESPIRATORY DEPRESSION. FURTHERMORE, THE TRAMADOL N-OXIDE MATERIAL WHEN ADMINISTERED ORALLY EXHIBITS ANALGESIA FOR A LONGER DURATION THAN AN EQUI-ANALGESIC AMOUNT OF TRAMADOL.
|
