| 摘要 |
<p>Disclosed is a stabilized pharmaceutical composition comprising a compound of the formula (I) wherein: X is selected from a group consisting of a cycloalkyl or phenyl optionally substituted with one or more substituents as defined, (R10)k moieties represent 1 to 3 substituents on the aromatic ring that can be the same or different and are independently selected as defined, R11 is a radical selected from a group defined, n is 0 or 1, Y is ûNH, -O-, -S-, or -NR-, k is 1-3, and p is 0-3. The composition is described to also contain excipient(s) in a concentration sufficient to bring the pH of the composition to at least 8. A method of stabilizing a compound of formula (I) is described. This comprises dry blending, dry granulating or wet granulating the compound with one or more pharmaceutically acceptable excipients and one or more basic excipients to form a pharmaceutical composition. The disclosure has been shown to inhibit Epidermal Growth Factor Receptor (EDF-R) kinase, a protein that contributes to tumor cell growth.</p> |
