Formulation and dosage form for the controlled delivery of therapeutic agents

摘要

Disclosed is a formulation for the controlled delivery of a therapeutic agent, the formulation comprising a therapeutic agent exhibiting greater absorption in the upper gastrointestinal tract than in the lower gastrointestinal tract, a permeation enhancer selected from the group consisting of EDTA, fatty acid permeation enhancers, acyl carnitines, and salicylates, and a non-ionic surfactant carrier capable of forming a bioadhesive gel, the formulation being prepared such that the formulation is released within the gastrointestinal tract as a liquid and forms a bioadhesive gel in-situ after a period of time.