发明名称 |
Metered dose inhaler |
摘要 |
The present invention relates to pressurized metered dose inhaler (pMDI) actuators (2) with laser drilled orifices and to medicinal aerosol solution formulation products comprising these actuators (2). In particular, the present invention relates to the optimisation of the output characteristics of drug solution formulations in hydrofluoroalkanes (HFAs) by use of pMDIs with actuators (2) with laser drilled orifices of specific dimensions. Moreover, the actuators (2) of the present invention allow the use of solution formulations with a high ethanol content and a high ratio of ethanol to active ingredients and thus, the use of poorly soluble active ingredients in solution formulations and allow the use of solution formulations which are substantially free of low volatility components. |
申请公布号 |
NZ534040(A) |
申请公布日期 |
2006.03.31 |
申请号 |
NZ20020534040 |
申请日期 |
2002.12.19 |
申请人 |
CHIESI FARMACEUTICI S |
发明人 |
DAVIES, REBECCA JAYNE;GANDERTON, DAVID;LEWIS, DAVID ANDREW;MEAKIN, BRIAN JOHN |
分类号 |
A61K9/08;A61K9/00;A61K9/12;A61K31/352;A61K31/56;A61K47/06;A61K47/10;A61K47/14;A61K47/34;A61M11/00;A61M11/08;A61M15/00;B05B15/02 |
主分类号 |
A61K9/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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