Vascular occlusion solid-phase agent with immobilised platelet binding agent

摘要

Disclosed is a composition for inducing thrombus formation in vivo comprising: a solid phase agent selected from a specified group, capable of binding a platelet specific component; and a platelet specific component, chosen from a specified group including von Willebrand Factor (VWF), where, upon delivery to the target vasculature it binds platelets onto the solid-phase agent and induces platelet activation. The disclosure allows for the purposeful induction of thrombosis for use in hyperplastic or neoplastic vasculature, arterio-venous malformations, or hemorrhaging vasculature. Of particular interest is the reduction in blood flow to cancer cells.