Osmotic delivery system

摘要

An osmotic pharmaceutical tablet comprising: (a) a single-layer compressed core comprising (i) a non-ripening drug having a solubility per dose less than about 1 mL-1, (ii) a hydroxyethylcellulose having a weight-average, molecular weight from about 300,000 to about 2,000,000, and (iii) an osmagent, wherein said hydroxyethylcellulose is present in said core from about 2.0% to about 20% by weight and said osmagent is present from about 15% to about 75% by weight; (b) a water-permeable layer surrounding said core; and (c) at least one passageway within said layer (b) for delivering said drug to a fluid environment surrounding said tablet.