Compositions comprising epothilones and their use for the treatment of carcinoid syndrome

摘要

Disclosed is an epithilone derivative of formula (I) wherein: A represents O or NRN, wherein RN is hydrogen or lower alkyl, R is H or lower alkyl RÆ is methyl, methoxy, ethoxy, amino, methylamino, dimethylamino, aminomethyl or methylthio, and Z is O or a bond. Additionally disclosed is a compound as described above in combination with a compound selected from: somatostatin, interferon, 5-fluorouracil, doxorubicin, cyclophosphamide, streptozotocin and a standard anti-diarrheal. The compounds described are used for the preparation of a medicament for the treatment of carcinoid syndrome or at least one neuroendocrine tumour (including Islet cell tumour, gastrinoma, or VIPoma) where there is resistance to standard systemic chemotherapy.