发明名称 |
Chiral separation, characterization and biological action of optically active isomers of digoxin |
摘要 |
Disclosed herein is the method for separation of enantiomers or isomers of digoxin. These isomers are to be used in the treatment of heart failure without adverse or unneeded cardiac actions in humans. Additionally what is claimed is an isolate with less or no cardiac contractile effect but with AV node slowing such that the composition would be an effective therapy for the control of the ventricular response in atrial fibrillation. Also disclosed are methods for assaying these isomeric compounds present in biological fluids to enable the separation of pharmacologic actions.
|
申请公布号 |
US2006069043(A1) |
申请公布日期 |
2006.03.30 |
申请号 |
US20040951900 |
申请日期 |
2004.09.29 |
申请人 |
SOMBERG JOHN C;RANADE VASANT V |
发明人 |
SOMBERG JOHN C.;RANADE VASANT V. |
分类号 |
C07J17/00;A61K31/704 |
主分类号 |
C07J17/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|