<p>This invention provides a practical synthesis route for 4,5-dihydroxypentane-2,3-dione (DPD), an unstable small molecule which is proposed to be the source of universal signaling agents for quorum sensing in bacteria. The synthesis route includes new intermediates and allows preparation of isotopically-labeled DPD and ent-DPD. The method provides sufficient quantities of DPD for study of spontaneous binding of borate to DPD, the signal for the marine bacteria V. harveyi</p>
申请公布号
WO2006034269(A1)
申请公布日期
2006.03.30
申请号
WO2005US33648
申请日期
2005.09.20
申请人
THE TRUSTEES OF PRINCETON UNIVERSITY;SEMMELHACK, MARTIN, F.;CAMPAGNA, SHAWN, R.;BASSLER, BONNIE, L.;FEDERLE, MICHAEL, J.
发明人
SEMMELHACK, MARTIN, F.;CAMPAGNA, SHAWN, R.;BASSLER, BONNIE, L.;FEDERLE, MICHAEL, J.