METHOD FOR DETECTING GENETIC MUTATION CAUSING BLOOD COAGULATION ABNORMALITY BY GENETIC ANALYSIS OF BLOOD COAGULATION FACTOR X

摘要

PROBLEM TO BE SOLVED: To provide a means for enabling the early diagnosis and morbidity risk judgment of a disease accompanied by blood coagulation abnormality. SOLUTION: This method for detecting the genetic mutation causing the blood coagulation abnormality (shortage or extension of blood coagulation time) is characterized by detecting the mutation of a base represented by 8313C and 19819A (each is shown with a position in the genome base sequence of the gene described in GenBank accession number AF503510 and with a base after the mutation) of the blood coagulation factor X gene. A method for detecting the mutation of the base. A method for examining a disease morbidity risk by the utilization of the detection method. A method for predicting reactivity with an agent for preventing and/or treating a disease accompanied by the blood coagulation abnormality. A method for selecting the agent for preventing and/or treating the disease accompanied by the blood coagulation abnormality. A method for determining the dosage of the agent for preventing and/or treating the disease accompanied by the blood coagulation abnormality. A gene having the mutation. A polynucleotide and a reagent kit each used for the method. And so on. COPYRIGHT: (C)2006,JPO&NCIPI