A PKA II anchoring disruption molecule or AKAP mimic, wherein said molecule or mimic is a polypeptide which comprises the following amino acid sequence: X<SUB>1</SUB> X<SUB>2</SUB> E X<SUB>3</SUB> X<SUB>4</SUB> A K Q I V X<SUB>5</SUB> X<SUB>6</SUB> X<SUB>7</SUB> I X<SUB>8</SUB> X<SUB>9</SUB> X<SUB>10</SUB> (sequence (1) ) or a peptidomimetic or analogue thereof is provided. Also provided are antibodies to the molecule, nucleic acid molecules comprising a sequence encoding the molecule and pharmaceutical compositions. A method of altering the PKA type II signalling pathway in a cell by administration of the anchoring disruption molecule or AKAP mimic, in particular to treat cardiovascular and metabolic disorders is also provided.
申请公布号
WO2006032909(A2)
申请公布日期
2006.03.30
申请号
WO2005GB03677
申请日期
2005.09.26
申请人
THE UNIVERSITY OF OSLO;JONES, ELIZABETH, LOUISE;LYGREN, BIRGITTE;CARLSON, CATHRINE, REIN;TASKEN, KJETIL;SCOTT, JOHN
发明人
LYGREN, BIRGITTE;CARLSON, CATHRINE, REIN;TASKEN, KJETIL;SCOTT, JOHN