| 摘要 |
<p>A composition provides a successful support for in-growth of new bone and adjacent tissue in a variety of medical procedures and may also function in drug delivery. The composition contains one or more bone growth materials, free collagen, a fluid and, optionally, other additives to modify the consistency, ionic nature, antibacterial nature, color, texture, smell, osteogenic capacity, resorptive time (if any) and, if necessary, the rigidity of the implant. These compositions can be formulated by including addition of energy (e.g., heating) using a variety of sources. In a preferred method of manufacture the composition is heated to dissociate the collagen fibers and allow at least some of the bone growth materials and any additives to be captured between adjacent fibers without denaturing any proteins in the collagen.</p> |
