| 发明名称 |
BIOSYNTHETIC GENE CLUSTER FOR THE MAYTANSINOID ANTITUMOR AGENT ANSAMITOCIN |
| 摘要 |
<p>The present invention relates to compositions and methods involving antitumor agents derived from bacteria. In particular, the present invention provides the ansamitocin biosynthetic gene cluster for the production of novel maytansinoid analogs with potent antitumor activity and reduced human toxicity.</p> |
| 申请公布号 |
EP1458737(A4) |
申请公布日期 |
2006.03.29 |
| 申请号 |
EP20020795666 |
申请日期 |
2002.11.21 |
| 申请人 |
UNIVERSITY OF WASHINGTON |
发明人 |
FLOSS, HEINZ, G.;YU, TIN-WEIN;LEISTNER, ECKHARD |
| 分类号 |
C12N15/09;A61K31/537;A61P35/00;C07D498/18;C12N1/15;C12N1/19;C12N1/21;C12N5/02;C12N5/10;C12N15/52;C12P1/06;C12P17/10;C12P17/18 |
主分类号 |
C12N15/09 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
