发明名称 |
MENTHOL-CONTAINING PREPARATION |
摘要 |
It is known that L-menthol controls smooth muscle contraction. In order to use L-menthol in practice as a digestive tract contraction inhibiting agent in digestive tract endoscopy, it is required to devise means of giving a formulation in which an L-menthol-containing formulation remains stable and transparent or little cloudy over a long time after the production and which shows little foaming at the administration. In the present invention, an antifoaming agent is further added to a formulation for inhibiting smooth muscle contraction or a peristaltic contraction in a digestive tract containing a L-menthol emulsion having an average particle size of less than 100nm. Thus, it is possible to obtain a formulation that remains stable over a long time, has a high light transmittance, and produces little foam when filled into a container and sprayed at a target area to inhibit contraction to facilitate observation of the area in endoscopic examination of the digestive tract etc.
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申请公布号 |
EP1640022(A1) |
申请公布日期 |
2006.03.29 |
申请号 |
EP20040746565 |
申请日期 |
2004.06.28 |
申请人 |
NIHON PHARMACEUTICAL CO., LTD. |
发明人 |
HAMAWAKI, TOMONORI;KATAOKA, YOSUKE;ISODA, TAKAKO |
分类号 |
A61K31/045;A61B1/273;A61B1/31;A61K9/107;A61K47/02;A61K47/10;A61K47/26;A61K47/34;A61K47/44;A61K49/00;(IPC1-7):A61K49/00 |
主分类号 |
A61K31/045 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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