发明名称 |
FAB LIBRARY FOR THE PREPARATION OF A MIXTURE OF ANTIBODIES |
摘要 |
The present invention provides combinations of specific binding proteins, such as immunoglobulins, that are designed to be true combinations, essentially all components of the combination being functional and compatible with each other. The invention further provides a method for producing a composition comprising at least two different proteinaceous molecules comprising paired variable regions, said at least two proteinaceous molecules having different binding specificities, comprising contacting at least three different variable regions under conditions allowing for pairing of variable regions and harvesting essentially all proteinaceous molecules having binding specificities resulting from said pairing. |
申请公布号 |
EP1639009(A1) |
申请公布日期 |
2006.03.29 |
申请号 |
EP20040748618 |
申请日期 |
2004.05.28 |
申请人 |
MERUS BIOPHARMACEUTICALS B.V.I.O. |
发明人 |
HOOGENBOOM, HENDRICUS, RENERUS, JACOBUS, MATTHEUS;LOGTENBERG, TON |
分类号 |
C07K16/22;C07K16/00;C07K16/10;C12N5/10 |
主分类号 |
C07K16/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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