TASTE MASKING RAPID RELEASE COATING SYSTEM

摘要

The invention relates to a tablet which rapidly releases a drug in the stomach of a patient comprising: a drug-containing core; a taste masking layer wherein said taste masking layer increases the weight of the core by between 5 and 100 percent by weight composed of a material which is generally insoluble in saliva at a neutral to basic pH and completely soluble in saliva at a pH of less than 6.5; and a spacing layer surrounding said core, wherein said spacing layer increases the weight of the core by between 5 and 100 percent by weight and substantially completely sequestering said core from said taste masking layer and being capable of rapidly exposing said core when exposed in the stomach of a patient; said taste masking layer preventing exposure of said spacing layer in the mouth of a patient for a period of at least 20 seconds after being placed into the mouth and being capable of rapidly exposing said spacing layer when in the stomach of a patient; wherein the taste-masked formulation disintegrates in the mouth of a patient in less than 90 seconds to form a suspension of particles; wherein the coated drug-containing core generally has a diameter of no larger than 1,500 micrometer.